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Speed of onset of local anaesthetics and another textbook correction!

Anaesthesia Coffee Break

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The Unknown Ice Fraction of Licknacane

The unknown ice fraction of Licknacane is. 25%. Around 25%. And those are the numbers that you see. Now you might see another example, which is, I think, tetra cane. Tetra cane has a very high pKa. Let's use an example now where the pKa of the drug is 8.4. So 10 to the power of negative one is going to be 0.1. Then 0.1 divided by 1.1 will give you approximately 9%. Or 9 to 10%. Yeah. Beautiful.

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