Was episode 79 too light on MDS for you? “Amateurs” you said, adjusting your sellotaped glasses. If so, you’re in the right place today as we prepare to look at classification, risk stratification and treatment of myelodysplastic syndrome. You also should seek out psychiatric attention, or perhaps just go outside. But in the meantime, enjoy this episode where we’ll dig deeper into the nitty gritty of MDS! We’ve got a lot to cover so we float about between intermediate and advanced for this episode.
TIMESTAMPS
1:11 - A Very Unhinged Intro
3:34 - Actual Content Starts Here
5:52 - Differentials for dysplasia
7:54 - Presentations of MDS
12:36 - MDS Subtypes
14:23 - MDS with del(5q)
18:29 - Lenalidomide in del(5q)
25:03 - MDS with SF3B1
29:05 - MDS with biallelic TP53 inactivation
30:26 - Bonus cytogenetic abnormalities that pop up
31:43 - Germline mutations that predispose to MDS and AML
37:14 - MDS with low blasts
38:08 - Ogata Score
39:26 - Hypoplastic MDS
44:03 - MDS with increased blasts
44:58 - MDS with increased blasts and fibrosis
46:22 - Breaking News - Blasts Should Now Be Counted By Flow
48:30 - Prognostic models for MDS
53:36 - Treatments for MDS
1:04:39 - Take Home Messages
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