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Speed of onset of local anaesthetics and another textbook correction!

Anaesthesia Coffee Break

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Increasing Lipoic Solubility of Local Anesthetic

When you increase the potency of local anesthetic, it actually means you're going to be using less of the local anesthetic. And a classic example is bupivicane versus lignicane. Bp Civicane is more lipid soluble. It's got more protein binding and it's more potent. Lignicane is less potent,. You're going to use more of the drug, which means that there isMore of the drug available to diffuse across. That refers back to that concentration gradient as part of fixed law of diffusion. But all those things come into play.

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