In Vivo Delivery: LNPs and Engineered Viruses

Dr. Alex Marson, MD, PhD, is a Senior Investigator at the Gladstone Institutes and a professor of medicine at the University of California, San Francisco. We discuss the biology of the immune system and cancer, and everyday choices that can increase or decrease your cancer risk, several of which are surprising but all of which are actionable. We also discuss immunotherapy, including how engineered T-cells can be used to defeat childhood and adult cancers. Dr. Marson explains CRISPR and gene editing to cure diseases, and we address the ethical questions surrounding gene editing in embryos, children and adults. This discussion is for anyone interested in avoiding cancer and/or seeking to understand the science and practical applications of immune- or gene-therapy.

Read the show notes at hubermanlab.com.

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Timestamps

(00:00:00) Alex Marson

(00:02:21) Diseases & Current Biological Landscape; AI & Computational Tools

(00:05:56) Immune System, Innate vs Adaptive Immune System

(00:10:55) Thymus, T Cell Selection; B Cells & Antibodies

(00:13:23) Sponsors: BetterHelp & Helix Sleep

(00:16:11) Immune System Health, Sleep, Diet; Genes

(00:20:56) Childhood Exposure & Allergy Prevention; Autoimmune Reactions

(00:25:27) Whole Body Immune Response, Cytokines & Fever; Antibiotics

(00:30:51) Cancer; Mutations & Cell Regulation; Smoking, BRCA Mutations, Sunlight

(00:38:27) BRAC Mutations, Mutagens, Pesticides

(00:42:33) Sponsor: AG1

(00:43:57) X-Rays & Airport Scanners, Carcinogen vs Mutagen, Charred Meat, Food Dye

(00:49:34) Immune-Based Cancer Treatment, Checkpoint Inhibitors, CAR T-Cell Therapy

(00:59:04) CRISPR, Immunotherapies

(01:02:52) Age & Cancer Risk; CAR T-Cells, Targets & Side Effects; Ketogenic Diet

(01:08:27) CRISPR Discovery & Mechanism

(01:17:06) CRISPR Precision, Risk & Benefit; CRISPR Technology Evolution

(01:20:57) Sponsor: LMNT

(01:22:17) CRISPR Cell Delivery, Clinical Trials; Treating Early Cancers & Prevention

(01:33:47) Liposomes, Engineered Viruses, Lipid Nanoparticles (LNPs), Vaccines

(01:39:57) COVID Pandemic & Trust in Science, mRNA Vaccine

(01:47:51) Sponsor: Function

(01:49:39) Drug Delivery to Cancer, Immunotoxins, T-Cell Engagers; AI Protein Targets

(01:55:45) CRISPR Embryo Modification, Ethics; Heritable Gene Editing, Diversity

(02:05:42) Deep Sequencing Embryos, Diversity; Overcoming Adversity & Resilience

(02:10:44) Upcoming Therapeutics, Autoimmunity & CAR T-Cells, CRISPR & Gene Function

(02:17:55) Banking T Cells or iPSCs?, Future of Cell Programming

(02:24:41) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter

Disclaimer & Disclosures

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