How Stress Drives Mitochondrial Dysfunction

What if feeling better didn’t have to take months or years to figure out, but could start today? On this episode of The Dr. Hyman Show, I sit down with Dr. Scott Sherr to talk about why so many people feel stuck in what he calls a “sympathetic spiral of doom.” Energy is low, recovery isn’t what it used to be, and there’s a constant sense of stress that doesn’t seem to resolve. We walk through what’s actually happening beneath the surface, why it can be so hard to break out of that pattern once you’re in it, and how to start shifting your energy and recovery. Watch the full conversation on YouTube, or listen wherever you get your podcasts. In this episode, we discuss: • Why you feel “tired but wired” and what it actually means for your body • What’s keeping your energy low even when nothing obvious is wrong • How stress from your life and environment builds up and keeps you stuck • Why calming down doesn’t always work—and what to focus on instead • How to start rebuilding your energy so your body can recover and adapt We shouldn’t have to wait for something to go wrong to take action. The goal is to help your body function better so you can actually feel it day to day. View Show Notes From This Episode

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(0:00) Introduction and guest Dr. Scott Scherer

(3:31) Understanding the sympathetic spiral of doom

(5:06) Symptoms and signs of sympathetic overdrive

(7:10) Sympathetic activation, mitochondrial function, and stress

(10:02) Mitochondria: their role and impact in the body

(12:31) Stress, metabolic dysfunction, and their effects

(17:43) Nervous system, mitochondria, and the cell danger response

(21:25) Survival, stress, and breaking the sympathetic spiral

(23:11) Contributors to stress: top-down and bottom-up

(25:56) Mitochondria, microbiome, and medication impacts

(29:38) Mitochondrial dysfunction and mental health

(32:19) Limitations of parasympathetic activation and addressing root causes

(36:46) How mitochondrial stress leads to fight-or-flight

(37:52) Steps to break the sympathetic spiral and support mitochondria

(42:41) Methylene blue: benefits, uses, and safety

(50:35) Methylene blue as an MAO inhibitor and for chronic infections

(57:17) Case studies, third-party testing, and Transcriptions' evolution

(1:02:36) Parasympathetic edge, recovery, and the GABA system

(1:07:44) GABA, supplements, and interventions for stress

(1:12:23) Addressing root causes and methylene blue usage

(1:17:29) Transcriptions products, sleep formula, and practitioner ecosystem

(1:19:49) OneBase Health, hyperbaric space, and final information