Agents as Proactive Executive Assistants

Jason Calacanis sits down with three CEOs building at the bleeding edge of the agentic revolution: Mitesh Agrawal (Positron AI), Alex Elias (Qloo), and Kash Ali (TaxGPT). They discuss the rapid rise of Open Claw, an open-source platform that is fundamentally changing work by allowing users to create autonomous agents. "Saving 30 minutes a day... that’s like getting three more weeks a year back." "I don't need a technical recruiter today." We explore how autonomous agents are moving beyond "Copilots" to become independent teammates:

• The AI Executive Assistant: How Mitesh Agrawal uses agents to automate inbox filtering and Slack drafts, recapturing 6% of his year.
• The Hiring Hiatus: Kash Ali screened 1,000 job applications in two hours with "flawless" accuracy, replacing 40+ hours of manual labor.
• The $1M One-Person Firm: How AI is solving the shortage of 340,000 accountants by allowing a single person to command an "army of agents".
• Democratizing Luxury: Scaling the "chauffeur and concierge" experience to everyone through taste-based AI and structured inference.
• Autonomous Media: A demo of an agent that transcribes, clips, and captions viral content in five minutes, a process that previously took an hour.The agent era is here. Are you building your replicant, or are you being left behind by a 10x more efficient workforceThis Week In Startups is made possible by:Notion - https://www.notion.com/twistQuadratic - https://www.Quadratic.ai/twistTimestamps: 00:00 Welcome to This Week in AI!03:17 How are CEO’s using OpenClaw?09:25 Notion - Notion brings all your notes, docs, and projects into one connected space that just works with AI built right in. Try Notion, with Notion Agent, at notion.com/twist00:19:09 — Automating the "Great Hiring Hiatus”00:19:20 Quadratic - Bringing the productivity boost of AI into your spreadsheets. Visit [quadratic.ai/twist](https://www.quadratic.ai/twist) to sign up and use the code TWIST to get one free month of their pro tier subscription.00:27:11 — Saving Independent Film with AI Extras00:33:04 — Solving the Global Accounting Crisis00:36:36 — The $1 Million One-Person Tax Advisory00:43:05 — Demo: The Autonomous Content Clipper0:00 Making Clips with OpenClaw01:07:39 — Micro-Agents vs. "Ultron”01:10:23 — The Developer, the CEO, and the AI Joke (Outro)Subscribe to This Week in AI on Apple: https://podcasts.apple.com/us/podcast...Thanks for watching!🤖 If you want to stay ahead of the curve on all things AI, make sure to join our community across all platforms:📩 Get the Weekly Newsletter: https://thisweekinai.ai/📺 Subscribe on YouTube: [   / @thisweekinaipodcast  ](   / @thisweekinaipodcast  )📸 Instagram: [www.instagram.com/thisweekinaipodcast](  / thisweekinaipodcast  )📱 TikTok: [www.tiktok.com/@thisweekinaipodcast](  / thisweekinaipodcast  )✖️X:https://x.com/ThisWeeknAIFollow Jason:X:   / jason  LinkedIn: [  / jasoncalacanis  ](  / jasoncalacanis  )*Thank you to our partners:09:25 Notion - Notion brings all your notes, docs, and projects into one connected space that just works with AI built right in. Try Notion, with Notion Agent, at notion.com/twist00:19:20 Quadratic - Bringing the productivity boost of AI into your spreadsheets. Visit [quadratic.ai/twist](https://www.quadratic.ai/twist) to sign up and use the code TWIST to get one free month of their pro tier subscription.Check out all our partner offers: https://partners.launch.co/