Rose Byrne has taken many forms on-screen. In Mary Bronstein’s film If I Had Legs I’d Kick You, she delivers a career-defining performance as a Long Island therapist and mother slowly unraveling under the weight of her child’s mysterious illness.

Watch our conversation on YouTube.

In the lead-up to Oscar Sunday, we return to our talk with Byrne, discussing the maternal madness at the heart of this film (6:30), the long, collaborative road to shaping the character (10:00), and what it was like to have Conan O’Brien as a scene partner (13:30). Then, Byrne reflects on her debut performance in Dallas Doll (19:45), the plays and poems that inspired her as a teenager (22:30), and a formative role in the cult classic Two Hands, opposite the late Heath Ledger (26:00).

In the back half, we unpack the sexism she faced in Hollywood in the aughts (32:40), her unexpected comedic breakthrough in Bridesmaids and Neighbors (37:15), and the fruitful collaborations with Seth Rogen that followed (39:50). To close, Byrne pays tribute to two of her enduring artistic influences—filmmaker David Lynch (45:00) and playwright Arthur Miller (47:00).

Original air date: October 12, 2025

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