Moving Toward Randomized Trials

Is there evidence that the ketogenic diet can cure schizophrenia?

Recent comments from HHS Secretary Robert F. Kennedy Jr. sparked headlines…and controversy. While “cure” isn’t the right word, the conversation has brought much-needed attention to an emerging field: metabolic psychiatry.

In this video, Dr. Bret Scher breaks down what the science actually shows about ketogenic metabolic therapy as a potential adjunctive treatment for serious mental illness, including schizophrenia, bipolar disorder, and major depressive disorder.

You’ll learn about:

1. What nutritional ketosis is and why brain energy matters for serious mental illness
2. How psychiatric conditions like schizophrenia, bipolar disorder, and major depressive disorder involve underlying metabolic dysfunction
3. Early evidence on ketogenic therapy for serious mental illness from Stanford, Edinburgh, and The Ohio State University
4. How consistent lived experiences aligned with emerging clinical data warrant serious scientific exploration
5. What new research is on the way

Ketogenic therapy is emerging as a serious metabolic strategy that may expand how we think about treating complex psychiatric conditions. We are now faced with the opportunity to study it rigorously, apply it thoughtfully, and ensure patients have access to every tool that could help.

💡Learn more about the ongoing research in metabolic psychology on our Clinical Trials page: https://www.metabolicmind.org/resources/science/clinical-trials/

🏛Check out our condition specific topic pages to see our best resources on keto for serious mental illnesses:

1. Keto for Schizophrenia: https://www.metabolicmind.org/resources/topics/schizophrenia/
2. Keto for Bipolar Disorder: https://www.metabolicmind.org/resources/topics/bipolar/
3. Keto for Depression: https://www.metabolicmind.org/resources/topics/keto-for-depression/

🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.

#MetabolicMind #KetogenicTherapy #Schizophrenia

Expert Featured:

1. Dr. Bret Scher
2. Baszucki Group Medical Director
3. https://x.com/bschermd

Resources Mentioned:

A pilot study examining a ketogenic diet as an adjunct therapy in college students with major depressive disorder

1. https://doi.org/10.1038/s41398-025-03544-8

Ketogenic Diet Intervention on Metabolic and Psychiatric Health in Bipolar and Schizophrenia: A Pilot Trial

1. https://doi.org/10.1016/j.psychres.2024.115866

A pilot study of a ketogenic diet in bipolar disorder: clinical, metabolic and magnetic resonance spectroscopy findings

1. https://doi.org/10.1192/bjo.2024.841

https://www.metabolicmind.org/resources/science/clinical-trials/

https://www.metabolicmind.org/thinksmart/

Free CME Clinician Trainings:

Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon.

Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-yt

Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.

Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/

About us:

Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.

Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.