Spermidine, autophagy, and fertility

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Longevity isn’t about just living longer, but rather living better and longer.

Today, I sit down with Dr. Greg Bailey, a former emergency room physician turned biotech investor who now operates at the forefront of longevity science. After a decade in emergency medicine, he transitioned into drug development and cutting-edge research focused on extending healthspan, not just lifespan. We get into the mechanics of ketosis and why metabolic flexibility may matter more than extreme dieting, and the growing role of AI in medicine. Beyond the tech, we address supplement credibility, flawed research, and why connection, purpose, and education remain foundational to real longevity.

If you’re serious about biohacking, metabolic health, and the future of regenerative medicine, this conversation sets the tone.

You’ll Learn:

[00:00] Introduction

[01:29] The creativity and absurdity Greg witnessed in emergency room patients

[03:14] Different motivations for pursuing longevity and how desired lifespan changes based on projected health

[07:46] Cutting-edge longevity interventions, including epigenetics and cellular reprogramming

[12:01] The UCLA study that reversed biological age by two years

[15:03] The supplement industry's crisis of trust, why 75% of studies fail replication, and the critical need for credible voices

[23:18] Mike Levin's revolutionary bioelectric limb regeneration

[33:57] What the ultimate longevity factor is, and today's epidemic of loneliness

[39:59] The two pathways to ketosis and why cells prefer ketones over sugar

[44:54] Ketones as a potential alcohol replacement for social occasions

[49:20] Ketones for brain health across all ages and spermidine's dramatic autophagy effects

[01:05:40] Greg's most influential teachers, his mother's profound impact, and my epiphanies I experienced

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Resources Mentioned:

Reversal of epigenetic aging and immunosenescent trends in humans by Fahy, G et al | Article

A Randomized Open-Label, Observational Study of the Novel Ketone Ester, Bis Octanoyl (R)-1,3-Butanediol, and Its Acute Effect on ß-Hydroxybutyrate and Glucose Concentrations in Healthy Older Adults by Stephens, E et al | Article

READ: The Body Electric by Robert O. Becker | Book

READ: A Horse Named Lonesome by Luke Storey | Website

A ketogenic diet extends longevity and healthspan in adult mice by Roberts, M et al | Article

Impact of polyphenol oxidase on the bioavailability of flavan-3-ols in fruit smoothies by Ottaviani, J et al | Article

Sprevive | Website

Urolithin A | Wikipedia

Timeline Mitopure | Website

Primeadine Spermidine | Website

Full show notes at lukestorey.com/qitone

Find more from Dr. Greg Bailey:

Dr. Greg Bailey | Website

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Keywords:

longevity science, healthspan, lifespan vs healthspan, aging research, biotech investing, drug development, emergency medicine, ketosis, ketone esters, exogenous ketones, metabolic health, metabolic flexibility, fasting, ketogenic diet, epigenetics, cellular reprogramming, limb regeneration, stem cells, senolytics, NAD pathways, AI in medicine, clinical trials, supplement credibility, regenerative medicine, spermidine, urolithin A, education and longevity, purpose and aging