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Speed of onset of local anaesthetics and another textbook correction!

Anaesthesia Coffee Break

00:00

Is Increased Lipid Solubility Associated With Increased Protein Binding?

I'm just literally the first Google kind of search I've done, frequency dependent blocking humans by Candido. In response, we concur with Stevens that as our study demonstrated, a frequency dependent action of local and aesthetics is unlikely to be a mechanism at work in stimulation induced following peripheral nerve injections. The next one is, why does increased lipid solubility translate to increase protein binding? Now that's a, that's a chemistry question. So if anyone has an answer to that, yeah, please share it with us.

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