How Much Better Can We Get on Our Opsin?

An opsin where the poor closes slower will conduct more than an opsin whose por closes faster, all other things being equal. So you can low down your obsens and use less lazer powert to get them to be activated. Obviously, i don't like that idea for various reasons that we've discussed, but it works. No one's shown a ten nanoamp opsin even in one photon. I think people have been close, but certainly noone's shown a hundred man a way up.

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Episode notes

Welcome back to Neurotech Pub!

This episode is part two of a two part series on optical methods for recording and stimulating neural activity. Our guests on this episode are Elizabeth Hillman, PhD, Mark Schnitzer, PhD, and Jacob Robinson, PhD. Last time we talked about optical recording methods, but in this episode we focus on optical stimulation methods.

Cheers!

Check out video and full transcript here: https://www.paradromics.com/podcast/episode-12-mind-control-with-lasers

00:00 | Intro

1:37 | Aspirational Papers

1:56 | Packer Lab

2:10 | What is the claustrum?

2:30 | Ian's paper (but only part of it!)

3:02 | Two-Photon Bidirectional Control and Imaging In Vivo

3:29 | Inferring Spikes from Calcium Imaging

5:45 | Neuropixels are now in humans

7:12 | Paper by Pachitariu et al

7:55 | Ian Oldenburg