Science, Interrupted: Part 1
Distillations | Science History Institute
Cohen and Boyer Achieve DNA Cloning
Stanley N. Cohen and Herb Boyer develop plasmid-based cloning, enabling replication of foreign DNA in E. coli.
Genetic engineering breakthroughs in the late 1960s and early 1970s came with a lot of promise—and peril too. Fears about what could happen with recombinant DNA experiments put scientists in the middle of a moral dilemma. Did they have a responsibility to consider how others might use their work? Or was their place simply to be on the lab bench? In this two-part episode, we'll share the story about the first time scientists stopped and considered the ramifications of their work, with a self-imposed moratorium. And we'll explore all the controversy that led to the historic pivotal meeting at the Asilomar Conference Grounds in 1975 to determine the future of genetic engineering.
CreditsHost: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer Music by Blue Dot Sessions
Resource ListA Deep Conversation with Jon Beckwith: A History of Scientific and Social Activism. University of California Television. YouTube.
Berg, Paul. "Paul Berg Letter." Wellcome Collection. Chemical Heritage Foundation: The Emergence of Biotechnology. Science History Institute.
Cobb, Matthew. As Gods: A Moral History of the Genetic Age. New York: Basic Books, 2021. Cohen, Stanley N. Science, Biotechnology, and Recombinant DNA: A Personal History. UC Berkeley. DNA Learning Center. "Asilomar Meeting."
Genetic Dreams, Genetic Nightmares. BBC. Fredrickson, Donald S. Asilomar and Recombinant DNA: The End of the Beginning.
DNA: The Secret of Life. IMDb.
Jurassic Park. IMDb. Late 1960s-Early 1970s Anti-War Marches. YouTube.
"Letter from Maxine Singer and Dieter Söll to Philip Handler." Lear, John. Recombinant DNA: The Untold Story. Goodreads. Mukherjee, Siddhartha. The Gene: An Intimate History. Simon & Schuster. McElheny, Victor. Attempting the Impossible at Asilomar. McElheny, Victor. Gene Transplants Seen Helping Farmers and Doctors. The New York Times, May 20, 1974. Nova: The Gene Engineers. Dailymotion. Protein Synthesis: An Epic on the Cellular Level. YouTube.
Rejection of Science Worries American Scientists. The New York Times, April 5, 1970. Rogers, Michael. The Pandora's Box Congress. Rolling Stone.
The Gene: PBS. PBS Learning Media. "The MacNeil/Lehrer Report: Genetic Engineering." American Archive of Public Broadcasting.
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