#25377
Mentioned in 2 episodes
Beyond Inheritance
Our Ever‑Mutating Cells, and a New Understanding of Health
Book •
Roxanne Khamsi's Beyond Inheritance argues that humans are genetic mosaics whose cells continually acquire mutations that shape health and disease.
Drawing on recent advances like single‑cell sequencing, she traces somatic mutations from embryonic development through aging, showing their roles in conditions from cancer to autoimmune and neurodegenerative diseases.
Khamsi also highlights examples of natural ‘revertant’ mutations that restore function and discusses implications for diagnostics, prevention, and novel therapies.
The book synthesizes history, patient stories, and cutting‑edge research to reframe how clinicians and patients think about genetic causation.
It aims to make complex genomic science accessible while urging broader clinical consideration of acquired mutations.
Drawing on recent advances like single‑cell sequencing, she traces somatic mutations from embryonic development through aging, showing their roles in conditions from cancer to autoimmune and neurodegenerative diseases.
Khamsi also highlights examples of natural ‘revertant’ mutations that restore function and discusses implications for diagnostics, prevention, and novel therapies.
The book synthesizes history, patient stories, and cutting‑edge research to reframe how clinicians and patients think about genetic causation.
It aims to make complex genomic science accessible while urging broader clinical consideration of acquired mutations.
Mentioned by
Mentioned in 2 episodes
Mentioned by 
Ira Flatow
40 snips
Your DNA is constantly mutating, and that’s a good thing
Recommended by 
Eric Topol
16 snips
Roxanne Khamsi: We Are All Genetic Mosaics
